What is Onpattro?
Onpattro (patisiran) is an FDA-approved prescription medication used to treat polyneuropathy in adults with hereditary transthyretin-mediated amyloidosis (hATTR). hATTR is a rare genetic condition where misfolded transthyretin (TTR) proteins accumulate as amyloid deposits in various tissues and organs, leading to nerve damage and other complications. Onpattro works by utilizing small interfering RNA (siRNA) to reduce the production of both mutant and wild-type TTR proteins, thereby decreasing amyloid deposits and alleviating symptoms associated with polyneuropathy.